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ncrease in the prescription of Benzodiazepines in the context of the SARS COV 2 pandemic.

European Statement

Clinical Pharmacy Services

Author(s)

Elena Elvira Ladrón de Guevara, Belen Sanchez Rodriguez, Misael Rodriguez Goicoechea, Marina Sanchez Valera, Diego Gámez Torres, Francisca Verdejo Reche, Inmaculada Alférez García

Why was it done?

The main aim of this study is to find out the prescriptions of benzodiazepine derivatives from 2018 to 2021 in the context of the SARS COV 2 pandemic and the variation in them. As a secondary objective, we will learn which benzodiazepine derivatives varied more.

What was done?

The most frequently recorded mental health problem is anxiety disorder and in the context of the SARS COV 2 pandemic, where an increase in anxiety cases has been evidenced, benzodiazepine derivatives (N05BA) have been one of the most prescribed pharmacological groups in most developed countries for this problem. Although its short-term benefits have been demonstrated, increasing its consumption may have long-term risks.

How was it done?

Retrospective, observational and cross-sectional study. The study period includes June 2018, June 2019, June 2020 and June 2021. The study population includes the 710.581 inhabitants associated with the prescribing doctors of benzodiazepine derivatives, from the study province.

What has been achieved?

N = 710,581, 21.61% (153,574) with a benzodiazepine prescription, 67.33% (103,416) women, between June 2018-June 2021. The prescribed benzodiazepine derivatives: alprazolam, Diazepam, diazepam / priridoxine, clotiazepam, lorazepam, ketazolam, clobazam, pinazepam, clorazepatodipotassium, bromazepam, bentazepam, diazepam / sulpiride, diazepam / sulpiride / pyridoxine.
June 2018: 35,800 prescriptions, 67’30% (24,085) women, June 2019: 37,601, 67.20% (25,262) women, June 2020: 39,547, 67.30% (26,622) women and June 2021: 40,626, 67, 60% (27,477) women.
From June 2018 to June 2019 prescriptions increased 5.03% (1,801), from June 2019 to June 2020 they increased 5.20% (1,946), from June 2020 to June 2021 they increased 2.73% ( 1,079), which represented a 13.48% increase in prescriptions from June 2018 to June 2021 (4,826).
The largest prescription increases were diazepam + 23%, lorazepam + 18%, bromazepam + 12.5%, and alprazolam + 12.3%. The largest prescription decreases were clotiazepam and bentazepam -100%, pinazepam -96’43% and clobazazam -22’45%.

What next?

Currently, the consumption of benzodiazepine derivatives has been increasing due to an increase in stress and anxiety situations and, in the context of the SARS VOC 2 pandemic, we have seen a progressive increase of 13.48% (4,826 prescriptions) from June 2018 to June 2021, with women being the user of 67.33% of prescriptions on average. These data allow us to know the current situation of the prescription of benzodiazepine derivatives to the population and to focus on mental health both in the validation of treatments and in pharmaceutical care.

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