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GLYOXYLIC ACID POISONING AFTER USE OF HAIR TREATMENT PRODUCTS: CLINICAL AND PHARMACEUTICAL APPROACH

European Statement

Clinical Pharmacy Services

Author(s)

Pons Maria, A; Fernández Huertas, L; Samblas Ruiz, M; Hernandez Silveira, L; Barceló Sansó, F; Juez Santamaria, C; Luque Mesa, JA

Why was it done?

This case describes a 23-year-old patient admitted with acute kidney injury (AKIN III) of unknown origin. Due to poor clinical progression, along with symptoms of scalp itching and redness, and the presence of calcium oxalate crystals in urine, glyoxylic acid poisoning was suspected. Glyoxylic acid is a component found in certain hair straightening products. The potential use of fomepizole as an antidote was considered, prompting a pharmaceutical intervention.

What was done?

A literature review was conducted on the use of fomepizole in poisonings caused by glyoxylic acid and ethylene glycol, considering that glyoxylic acid is an intermediate metabolite in the toxic pathway of ethylene glycol.

How was it done?

The mechanism of action of fomepizole was analyzed as a competitive inhibitor of the enzyme alcohol dehydrogenase, assessing its ability to block the conversion of glyoxylic acid into toxic metabolites such as oxalic acid, which is responsible for renal damage. To evaluate the feasibility of using the antidote, the National Institute of Toxicology was consulted. After reviewing the case, and given that more than 72 hours had passed since exposure to the toxin, its administration was ruled out. Supportive treatment already initiated was continued, including fluid therapy, bicarbonate, thiamine, and pyridoxine. The patient showed progressive improvement in renal function without requiring dialysis.

What has been achieved?

The multidisciplinary approach enabled the identification of the toxic etiology and helped prevent major complications. The case highlighted the key role of the hospital pharmacist in the evaluation of antidotes.

What next?

Similar poisoning scenarios—both uncommon and typical—will be reviewed to establish well-defined clinical pathways that allow for rapid and coordinated action in case antidotes such as fomepizole need to be used. This review will help improve the preparedness of both pharmacy and clinical teams for toxicological situations not currently covered by existing protocols.

A POCKET GUIDE TO MINIMISE USER ERRORS RELATED TO PATIENTS’ MEDICATION LISTS IN THE ELECTRONIC CHARTING SYSTEM MEONA

European Statement

Patient Safety and Quality Assurance

Author(s)

E Biringer1,2, K Skaare-Fatland1, E Tverborgvik3
1Helse Fonna Local Health Trust, Haugesund, Norway, eva.biringer@helse-fonna.no
2Western Norway University of Applied Sciences, Stord, Norway
3Sjukehusapoteka Vest HF, Stord, Norway

Why was it done?

Why was it done?
The aim was to reduce the risk of medication errors arising during the registration and reconciliation of patients’ medication lists in the electronic charting system MEONA (Mesalvo GmbH, Freiburg, Germany) at patient admission. Prior to the intervention, medication errors were frequent, most likely due to limited MEONA proficiency among newly employed staff and a complex procedure for importing information about patients’ current medications from multiple sources, i.e. the electronic patient records, the Summary Care Record («Kjernejournal») and the Prescription Intermediary («Reseptformidleren»). The initiative was made in 2022 in a mental health hospital in Norway.

What was done?

What was done?
A concise pocket guide was developed for use by health personnel responsible for the registration and reconciliation of medication lists at the acute mental health ward.

How was it done?

The process of registration and reconciliation of medication lists was standardised and visually illustrated by simplified step-by-step illustrations of the user-interfaces of MEONA. The illustrations were included in a two-page pocket-sized brochure along with illustrations pertaining to electronic registrations of patient information in the electronic patient administrative- and laboratory systems. The hospital pharmacist advised the development of the brochure. The communications department of the health trust created the illustrations and lay-out of the brochure.

What has been achieved?

A qualitative evaluation was conducted based on feedback from end-users of the brochure, i.e. the physicians regularly performing medication-related operations in MEONA. They all reported a reduction in erroneous registrations and less time spent on hazzles related to medication reconciliation after the pocket guide was implemented. A newly employed junior doctor stated:
“I think the brochure is excellent! I would have had significantly more trouble during my shifts if I hadn’t had this little guide with me.”

What next?

This simple intervention likely contributed to reducing the risk of medication-related errors in the mental health hospital. Hospital pharmacists could develop similar brochures in other hospitals with electronic charting systems subject to user errors. The efficiency of such pocket guides in terms of reducing erroneous registrations and time spent on registrations should be measured prior to and after their introduction.

DEVELOPMENT OF CLINICAL PHARMACY IN A HOME HOSPITALIZATION SERVICE: IMPLEMENTATION OF NEW ACTIVITIES.

European Statement

Clinical Pharmacy Services

Author(s)

D. AUDEGEAN, C. HAMELIN, C. CONTENT, C-H. BLANCHER

Why was it done?

The care of patients receiving home hospitalization is complex. These patients experience multiple transitions throughout the care process and are treated by many health professionals, both in hospitals and private practitioners. This increases the risk of losing important information.

What was done?

To improve safe medication management and make treatment delivery more efficient, new clinical pharmacy activities were implemented.

How was it done?

A medication review and a pharmaceutical consultation were added to pre-admission visits. Unintended discrepancies in patients’ treatment lists and the corresponding pharmaceutical interventions were identified and analysed. A French program, Patient Self-Administration of Medications, to support patients in managing their own medications was introduced following an initial assessment of autonomy by a clinical pharmacist. Information collected during these pharmacy activities was shared with community healthcare providers. The satisfaction of the home hospitalization medical team was also assessed.

What has been achieved?

Over six months, 41% (n = 34) of patients admitted to home hospitalization from our hospital received the new pharmacy service. A total of 38 medication reviews were done. At least one unintended discrepancy was found in 55% (n = 21) of these reviews. The most frequent problem was unintentional treatment omission. In total, 39 pharmaceutical interventions were made. Their clinical value was rated as “moderate” in 69% (n = 27) of cases. Most patients (47.5%) had an autonomy score of 0. Liaison letters were sent to community healthcare providers using secure messaging. All physicians (100%, n = 4) said they were “completely satisfied” with the new clinical pharmacy activities.

What next?

These new clinical pharmacy services helped ensure the safe use of medications in home care patients. Sharing information with community providers improved the link between hospital and community care and supported continuous medication management. However, current staffing levels do not allow all patients to benefit. Involving pharmacy technicians in medication reconciliation may help increase the number of reviews performed. The unanimous satisfaction of the medical team supports continuing these activities in the home hospitalization service.

RISK-DRIVEN TRANSFORMATION: INTEGRATED RISK MATRIX WITH PDCA AND KPIS IMPROVES MEDICATION SAFETY AND OPERATIONAL PERFORMANCE

European Statement

Patient Safety and Quality Assurance

Author(s)

Vanusa Barbosa Pinto, Andréa Cássia Pereira Sforsin, Cleuber Esteves Chaves, Carolina Broco Manin, Priscila Faria França, Amanda Magalhaes Vilas Boas Cambiais, Carolina Ferreira Dos Santos, Lidiane Baltieri Gomes, Priscilla Alves Rocha, Maria Cleusa Martins

Why was it done?

The Pharmacy Division of a large tertiary hospital implemented structured risk governance, anchored by a risk matrix integrated into strategic planning and monitored by Key Performance Indicators (KPIs). The primary goal was to reduce risks across the entire medication use process—from selection to administration—using the matrix to guide continuous improvement cycles (PDCA) and ensure proactive, predictive risk management.

What was done?

Tertiary hospitals with complex medication processes often face a high incidence of adverse events and waste due to fragmented risk management. The aim was to proactively mitigate risks classified as high and extreme, not only enhancing medication safety but also improving efficiency and operational response time. The initiative also sought to strengthen the internal safety culture by encouraging increased near-miss reporting.

How was it done?

The project involved an end-to-end mapping of pharmaceutical care in 2024, with risk scoring (probability x consequence). Critical KPIs were defined: service level, prescription evaluation rate, adverse event reports for compounded products, and near-miss reports. Results were reviewed in multi-professional committees to guide PDCA improvement cycles. One specific action plan involved implementing Personal Digital Assistants (PDAs) in medication distribution to enhance traceability.

What has been achieved?

Between 2024 and 2025, the absolute number of risks classified as extreme decreased, and five risks reduced their criticality. The intervention demonstrated objective gains: service level increased from 77.82% to 84.40%; adverse event reports for compounded products decreased from 11 to 6; and the average monthly near-miss reports increased from 34 to 44, strengthening the safety culture. Notably, the PDA implementation contributed to the medication traceability rate increasing from 12.5% to 50.2%.

What next?

This governance model, focused on risk mitigation through PDCA cycles and critical KPIs, proved to be a practical and effective strategy for achieving sustainable gains in medication safety and efficiency. The practice is highly transferable and scalable, reinforcing the strategic role of the hospital pharmacy in integrating planning, quality, and technological innovation, and serving as a benchmark for other high-complexity institutions.

ASSESSMENT OF THE COMPLIANCE OF READY-TO-USE NEONATAL PARENTERAL NUTRITION ADMIXTURES PRESCRIPTIONS WITH THE FRENCH NATIONAL HEALTH AUTHORITY RECOMMENDATIONS

European Statement

Patient Safety and Quality Assurance

Author(s)

S. CHIKHI, A. DIALLO, X. DEVIOT

Why was it done?

Ready-to-use neonatal parenteral nutrition admixtures (RTUs) are indicated for preterm infants when enteral or oral nutrition is either impossible or insufficient. To meet patients\’ specific nutritional needs, some RTUs must be supplemented with vitamins, trace elements or electrolytes. Considering the microbiological contamination risk associated with supplementation procedures, the French National Health Authority (HAS) stated that supplemented RTUs are safer when prepared by the pharmacy, in controlled atmosphere areas, rather than in healthcare services. It also recommended no more than three supplementations.

What was done?

To centralise RTUs supplementation within our parenteral nutrition unit, we carried out a retrospective analysis of prescriptions from 2023 and 2024 to evaluate their compliance with HAS recommendations.

How was it done?

Prescriptions were extracted from the prescription support software (Logipren). For each prescription, the number of supplements was noted, and the quantities added were evaluated against the maximum limits indicated in the Summary of Product Characteristics (SMPC).

What has been achieved?

A total of 1,073 prescriptions for 5 different RTUs were recorded. 91% (979) of prescriptions contained less than 3 additives. 9% (94) of prescriptions contained more than 3 supplements. 97% (91) of these prescriptions were for Numeta.
Regarding the compliance of added quantities, 7 prescriptions had a sodium level exceeding the authorized limit and 91 prescriptions involved supplementation with small volumes of zinc, despite the insufficient information on the feasibility of adding it.

What next?

To reduce the risk of infection and preparation errors, according to HAS recommendations, supplementation of RTUs with fewer than 3 additives, previously done in the neonatal care unit, is now performed in the pharmacy. Meanwhile, we suggested that physicians prioritize the prescription of individualized parenteral nutrition over supplemented Numeta when more than 3 supplements are required.

DETERMINATION OF THE PH OF SELECTED ANTI-INFECTIVES FOR SAFE INTRAVENOUS ADMINISTRATION

European Statement

Clinical Pharmacy Services

Author(s)

L. Čermanová, V. Slezáková, J. Babiaková, D. Fábiánová, S. Porubcová

Why was it done?

Phlebitis is one of the most common complications of infusion therapy. Intravenous drugs with extreme pH values (9) may chemically irritate or damage the venous endothelium, triggering an inflammatory response. Understanding the pH of intravenous anti-infectives is essential for clinical decision-making to prevent infusion-related complications.

What was done?

The aim of this work was to determine the pH values of selected intravenous anti-infectives administered at the National Institute of Cardiovascular Diseases, Bratislava (NÚSCH, a. s.) due to their potential to cause endothelial damage.

How was it done?

A literature review was performed to collect available data on the pH of reconstituted and diluted anti-infectives used at NÚSCH, a. s. Sources included Summaries of Product Characteristics, ASHP Injectable Drug Information®, pharmaceutical recommendations of Hôpitaux Universitaires de Genève, and relevant scientific publications.
The criteria used to select anti-infectives for pH analysis were a complete lack or insufficient information on the drug’s pH, reported pH values approaching the extreme thresholds of 5 or 9, and excessively wide pH ranges exceeding these limits.
Subsequently, the pH of 21 selected drugs was measured at 37 commonly administered concentrations (including ready-to-use formulations) using a glass-electrode pH meter (XS pH 7 Vio portable pH meter; electrode CHS ChemFlex). The diluents used were 0.9% sodium chloride solution, 5% glucose solution, and water for injection.

What has been achieved?

A table summarising selected anti-infectives at commonly administered concentrations, along with their mean pH values (± standard deviation) was compiled. Dilution volumes used in clinical settings with either 0.9% sodium chloride or 5% glucose solution for extremely acidic or alkaline medications did not appear to significantly modify pH in a way that would affect vascular access choice.
The pH values enable the identification of anti-infectives with a higher potential risk of phlebitis and support the selection of the most appropriate vascular access device.

What next?

The results will be applied in developing institutional recommendations for the dilution and administration of anti-infectives, supporting safer infusion practices and the prevention of chemically induced phlebitis across NÚSCH, a. s. wards. They will also inform staff training and may contribute to the reduction of medication errors.

ELECTRONIC PRESCRIPTION INTEGRATION: ACHIEVING 98% COVERAGE AND REDUCING TRANSCRIPTION ERRORS

European Statement

Patient Safety and Quality Assurance

Author(s)

VB Pinto, CSA Souza, NL Mizutani, RP Santos, MA Dias, ACP Sforsin

Why was it done?

The unification of two outpatient prescription platforms into a single, institutional electronic system was carried out. The initiative was led by a multidisciplinary team (pharmacists, physicians, and systems analysts) from a public, tertiary care hospital.

What was done?

Despite the high rate of electronic prescribing (92%), the coexistence of the two systems generated data fragmentation, rework, and exposed patients to unnecessary risks of transcription errors. The central objective was, therefore, to unify the process to universalize the use of electronic prescribing and, consequently, reduce transcription errors, strengthening patient safety and pharmaceutical care.

How was it done?

The intervention took place between July and September 2025. Actions included the technical integration of the systems into a single platform, the development of new standardized prescribing protocols, and training for prescribers. The impact was evaluated by monitoring the electronic prescribing coverage percentages and transcription errors rates at the outpatient level before and after implementation.

What has been achieved?

The integration demonstrated fast and significant results. Electronic prescription coverage increased from 92% to 98% in just one month after unification. In parallel, there was a progressive and sharp reduction in transcription errors: from 8.5% (pre-implementation) in July to 2.7% in September (after integration), representing a 68% decrease in the manual correction rate.

What next?

This initiative demonstrates the importance of technological unification for the advancement of Hospital Pharmacy. The model is highly replicable for other institutions dealing with fragmented electronic prescribing systems. The integration of systems has a direct and measurable impact on patient safety, establishing universal electronic prescribing as an efficient care standard and proof against transcription errors.

THE CRUSHING FACTORY SAFE PHARMACOTHERAPY THROUGH ENTERAL FEEDING ACCESS – EXPERIENCES AND GOOD PRACTICES FROM THE UNIVERSITY CLINICAL CENTRE IN GDAŃSK

European Statement

Clinical Pharmacy Services

Author(s)

Ewelina Lubieniecka – Archutowska, Bogusława Szmaja, Dorota Świtkowska, Agnieszka Prusko, Magdalena Jaśkowska, Marzena Mielczarek – Kęska, Urszula Dobrzycka – Magulska, Wioletta Kaliszan

Why was it done?

Enteral nutrition therapy plays a crucial role in the management of patients who cannot meet their nutritional needs orally. Besides providing essential nutrients, enteral feeding access often serves as a route for drug administration, which requires specific knowledge about drug compatibility and pharmacotherapy safety among healthcare professionals.
The aim of this project was to improve the safety and effectiveness of pharmacotherapy administered through enteral feeding access at the University Clinical Centre in Gdańsk (UCC).

What was done?

Based on literature review and institutional experience, the main challenges identified were related to the selection of appropriate medicines and pharmaceutical forms, as well as to the preparation and administration techniques used by nursing staff. To address these issues, several measures were implemented within UCC to enhance pharmacotherapy safety in patients with artificial enteral access.

How was it done?

A procedure titled “Principles of Administering Medicinal Products to Patients Receiving Enteral Nutrition via Feeding Tube or Gastrostomy” was developed and implemented. Within the hospital information system (Clininet), a dedicated list of medicines that must not be crushed or administered via enteral routes was introduced and made visible to physicians and nurses to support safe prescribing. Clininet also allows physicians, nurses, and dietitians to request pharmacotherapeutic consultations from hospital pharmacists. Pharmacists analyze and, when necessary, modify patients’ therapy. Medicines suitable for administration through enteral access were added to the hospital formulary, enabling physicians to choose formulations appropriate for crushing or alternative routes of administration. The hospital pharmacy introduced the so-called “Crushing Factory” – a centralized service where pharmacists prepare R.PEG-labeled medicines in safe forms and doses for enteral administration. Each administration is recorded in the patient’s medical documentation.

What has been achieved?

The implemented system led to:
• fewer prescribing and administration errors
• reduced drug loss and preparation mistakes
• fewer interactions and adverse effects
• compliance with accreditation standards for medication safety
• lower treatment costs and fewer pharmacological interventions
• reduced nursing workload and improved efficiency

What next?

Expand staff education on enteral pharmacotherapy, standardize training materials, monitor outcomes, introduce patients pharmaceutical discharge summaries and implement solutions hospital -wide to improve safety and continuity of care.

CYBER ATTACK! IS YOUR PHARMACY TEAM READY?

European Statement

Patient Safety and Quality Assurance

Author(s)

Sandra Oliver, Chief Clinical Information Officer, Pharmacy and Medicines.
Chris Green, Director of Pharmacy and Medicines Optimisation

Why was it done?

We describe how our hospital experienced a cyber-attack which resulted in the electronic patient record and other systems being taken offline, including our electronic prescribing system.

What was done?

We describe our response to the cyber-attack and the considerations necessary to replace an entire hospital’s electronic prescribing system with paper. We also describe the co-dependencies with other previously electronic departments and systems, and communications with partner organisations.

How was it done?

The conversion from electronic to paper prescribing was led by the pharmacy team. Initially, this was via a printed downtime solution from the electronic prescribing system, which then required transcription to a paper prescribing chart. This generated a number of logistic, practical and safety issues which were managed by the pharmacy team. We then describe how the hospital was converted back to electronic prescribing over the course of one day, and how the pharmacy team was pivotal to that.

What has been achieved?

We were able to successfully take our hospital off electronic prescribing and initiate a paper-based downtime solution that ran over several days, and then return the hospital to electronic prescribing. Recovery efforts involved pairing prescribers with pharmacists across wards, establishing a pharmacy command centre, coordinating medication administration on ePMA, and communicating service updates across the Trust. Third-party services were reinstated, and recovery was prioritised by acuity, with the least acute wards addressed first. During the downtime period, we actively encouraged the pharmacy team to log patient safety concerns, or ideas to improve the downtime process which were reviewed and acted on in real time and as part of the post-recovery review.

What next?

We have learned several valuable lessons from the downtime experience which we have taken forward as part of our revised business continuity plan. This includes a review of specialist prescribing situations for example insulin, how we contact and work with partner organisations, the robustness of our downtime printer setup, and training material for clinical staff who at the time of the cyber-attack, had never used a paper based prescribing system. This case study serves as a valuable resource for healthcare organisations seeking to strengthen their cybersecurity and business continuity strategies.

IMPLEMENTATION OF INTRAVENOUS WORKFLOW TECHNOLOGY FOR PEDIATRIC CHEMOTHERAPY: ENHANCING SAFETY, COMPLIANCE, AND OPERATIONAL EFFICIENCY

European Statement

Patient Safety and Quality Assurance

Author(s)

Natalie Kuchik PharmD, MS, BCSCP and Jacalyn Rogers PharmD, MS, BCPS, CPEL, FASHP

Why was it done?

Pediatric chemotherapy compounding requires exceptional precision and strict adherence to USP and standards due to the high-risk nature of the medications and vulnerable patient population. Traditional manual compounding workflows are prone to human error and operational inefficiencies, especially in busy hospital settings. To address these challenges, IV workflow technology was implemented to enhance patient safety, improve compliance, and streamline pharmacy operations.

What was done?

An IV workflow technology system was introduced in a pediatric hospital pharmacy to support chemotherapy compounding. The system included barcode scanning for drug and diluent verification, image capture of each preparation step, and remote pharmacist verification. This allowed pharmacists to review compounding steps in real time without being physically present in the cleanroom, improving both safety and workflow efficiency.

How was it done?

The implementation was carried out prospectively, with pharmacists transitioning to remote in-line verification using the IV workflow platform. The system flagged incorrect drug or diluent scans and captured images of each preparation step for pharmacist review. This setup enabled pharmacists to detect and intervene in real time when errors occurred, such as incorrect labeling or volume discrepancies. Data were collected on scan alerts, image-based interventions, and workflow metrics, including preparation throughput and pharmacist time allocation.

What has been achieved?

The technology successfully identified all instances of incorrect drug and diluent selections before finalization, significantly reducing the risk of medication errors. Image review further enhanced error detection, particularly for labeling and preparation accuracy. Removing pharmacists from the cleanroom improved workflow flexibility and reduced interruptions, resulting in a 25% increase in preparation throughput. Compliance with USP and standards improved due to automated documentation and verification processes.

What next?

Future steps include expanding the use of IV workflow technology to other high-risk compounding areas and evaluating its impact on broader pharmacy operations. Additional enhancements may include integrating the system with electronic health records and exploring further automation to support scalability. Continued monitoring of safety, compliance, and efficiency metrics will guide optimization and inform best practices for pediatric and adult oncology settings.